Senior Staff Engineer, Modeling
Description For Senior Staff Engineer, Modeling
Takeda Pharmaceuticals is seeking a Senior Staff Engineer specializing in Modeling to join their Synthetic Molecule Process Development (SMPD) team. This role combines advanced engineering expertise with pharmaceutical development, focusing on crystallization process development and population balance modeling. The position offers an opportunity to work at the intersection of chemical engineering and pharmaceutical science, utilizing cutting-edge modeling and simulation approaches to optimize drug development processes.
The role involves leading the development of robust, cost-effective processes for new small-molecule pharmaceuticals, with a particular focus on crystal form control and particle size distribution. The successful candidate will leverage expertise in crystallization kinetics, mass/heat transfer, and mathematical modeling to tackle complex challenges in particle engineering. They will be responsible for establishing scale-up and scale-down models using both first-principle and data-driven approaches.
Working within the Process Engineering & Technology Group, this position offers the chance to collaborate with cross-functional teams including Automation, Manufacturing, and Process Engineering experts. The role combines hands-on technical work with strategic leadership, requiring both deep technical expertise and strong communication skills to influence decision-making across the organization.
Takeda offers a comprehensive benefits package including competitive salary, medical/dental/vision insurance, 401(k) with company match, and various other benefits. The company's commitment to putting patients first and focus on innovation makes this an ideal opportunity for someone looking to make a significant impact in pharmaceutical process development while working for a global industry leader.
The position requires a Ph.D. or postdoctoral fellowship in Chemical Engineering or related field, along with significant industry experience in crystallization modeling and process development. This role represents an excellent opportunity for an experienced engineer to advance their career while contributing to the development of life-changing medications.
Responsibilities For Senior Staff Engineer, Modeling
- Lead crystallization process development using advanced modeling and simulation
- Develop and validate predictive crystallization models
- Design and execute experimental workflows with PAT integration
- Collaborate on developing digital twins for crystallization processes
- Drive adoption of in-silico first approach
- Provide expert technical leadership in crystallization modeling
- Review and communicate modeling outcomes to stakeholders
- Author technical reports and regulatory filings
- Stay current with emerging trends in crystallization modeling
- Champion knowledge-sharing and training across the organization
Requirements For Senior Staff Engineer, Modeling
- Ph.D. or postdoctoral fellowship in Chemical Engineering or related pharmaceutical science with 3+ years of relevant industry experience
- Strong knowledge of crystallization, filtration, drying processes
- Strong knowledge of transport phenomena and thermodynamics
- Experience with crystallization and particle engineering modeling software
- Experience with CFD modeling software
- Proficient in communicating and data collection from systems
- Experience with Matlab, Python, R, SQL, and good coding practices
- Strong analytical and problem-solving skills
- Excellent communication skills
- Good time management and prioritization skills
Benefits For Senior Staff Engineer, Modeling
- Medical, dental, and vision insurance
- 401(k) plan with company match
- Short-term and long-term disability coverage
- Basic life insurance
- Tuition reimbursement program
- Paid volunteer time off
- Company holidays
- Well-being benefits
- 80 hours of sick time
- 120 hours of paid vacation for new hires
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