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Principal Prediction & Insights Applications Engineer, Small & Large-Molecule Discovery

A biopharmaceutical company focused on developing innovative medicines for patients fighting serious diseases.
San Diego, CA, USAPrinceton, NJ, USACambridge, MA, USA
$155,000 - $170,000
Machine Learning
Principal Software Engineer
Hybrid
5,000+ Employees
10+ years of experience
AI · Healthcare · Biotech

Description For Principal Prediction & Insights Applications Engineer, Small & Large-Molecule Discovery

Bristol Myers Squibb is seeking a Principal Prediction & Insights Applications Engineer to lead their AI/ML initiatives in drug discovery. This role sits at the intersection of software engineering, machine learning, and drug discovery, focusing on building cutting-edge applications that accelerate both small-molecule and biotherapeutic invention.

The position offers a unique opportunity to work with state-of-the-art technologies including GenAI, molecular prediction models, and modern MLOps practices. You'll be responsible for developing intuitive software products and robust model-ops practices that help scientists make better decisions and iterate faster in their drug discovery efforts.

As a principal engineer, you'll lead the technical strategy and implementation of AI-native applications, working with technologies like React, Python, FastAPI, and various ML frameworks. You'll be integrating cutting-edge models like AlphaFold and RoseTTAFold, while also building conversational analytics and "copilot" agents using modern GenAI frameworks.

The role offers competitive compensation ($155,000-$170,000) plus benefits, and provides the opportunity to work with cross-functional teams of scientists and engineers. You'll be directly contributing to the development of new therapeutics while working at the forefront of AI/ML technology in the pharmaceutical industry.

This position requires a blend of technical expertise in software engineering and machine learning, domain knowledge in drug discovery, and leadership skills. You'll be working in a hybrid environment across multiple possible locations (San Diego, Princeton, or Cambridge Crossing), contributing to BMS's mission of transforming patients' lives through science.

The ideal candidate will have 10+ years of industry experience (or 7+ with an advanced degree), deep expertise in molecular modeling and AI/ML, and a track record of delivering production-grade applications. This is an excellent opportunity for someone looking to make a significant impact at the intersection of technology and healthcare.

Last updated 4 days ago

Responsibilities For Principal Prediction & Insights Applications Engineer, Small & Large-Molecule Discovery

  • Own strategy and delivery of GenAI-native applications and predictive-model workflows
  • Champion predictive-model use-cases across medicinal chemistry and biologics
  • Integrate agentic genAI frameworks to create conversational analytics
  • Deliver full-stack applications with React/Next.js fronts and Python/FastAPI & GraphQL services
  • Stand up automated pipelines for data curation and model deployment
  • Mentor cross-disciplinary team of full-stack and ML engineers
  • Partner with discovery leads and IT operations
  • Influence budgeting and make-vs-buy decisions for AI tooling

Requirements For Principal Prediction & Insights Applications Engineer, Small & Large-Molecule Discovery

Python
React
TypeScript
  • 8-10 years building software or ML solutions for medicinal chemistry, biologics engineering, or high-content screening
  • Practical mastery of molecular-design toolkits
  • Demonstrated success with LLMs, diffusion models, GNNs, structure-prediction models
  • Modern MLOps experience
  • M.S. or Ph.D. in Computer Science, Machine Learning, Computational Chemistry/Biology, OR related field
  • 10+ years industry experience (or 7+ years with advanced degree)
  • Leadership and communication skills

Benefits For Principal Prediction & Insights Applications Engineer, Small & Large-Molecule Discovery

Medical Insurance
Dental Insurance
Vision Insurance
401k
Parental Leave
Mental Health Assistance
Education Budget
  • Medical, pharmacy, dental and vision care
  • Wellbeing support and employee assistance programs
  • 401(K)
  • Short and long-term disability
  • Life insurance
  • Paid national holidays
  • Up to 120 hours of paid vacation
  • Paid volunteer days
  • Parental leave
  • Tuition reimbursement
  • Fertility/infertility benefits
  • Child, elder and pet care resources

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